Full episode · 1 h 50 m

From Wet Lab to RL Env: 10,000 Drug-Discovery Campaigns in a Weekend — Ian Quigley, Leash Bio

Latent Space · Shawn Wang (swyx) & Alessio Fanelli with Ian Quigley

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The best minutes

1. 46:24Public chemistry data can encode the chemist, not the chemistry6 min
2. 28:15A four-billion-measurement contest found a generalization gap7 min
3. 1:17:04Measured chemical landscapes let agents run thousands of campaigns7 min

Also worth watching

1. 1:03:18Protein mutations create experimental negatives for binders6 min
2. 1:42:49Lumacaftor-like hits can flag misfolded proteins4 min
3. 9:14Multiple barcodes expose DNA-binding false positives5 min
4. 1:28:26Leash reached mouse PK/PD in six months3 min
5. 15:24Screening many proteins reveals quirks in each library4 min

Skip the small-molecule primer, the later drug-economics and partnering discussion, and the final sequencing and purification bottlenecks.

Published Oct 14, 2026.