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All-In · 2 min · Mar 26, 2026

Johnson describes a calmer response to conflict after 5-MeO-DMT

Bryan Johnson describes feeling more playful and handling a conflict with his partner without escalating. It offers a concrete example of the changes he noticed after the experience.

Bryan Johnson

Bryan Johnson is a longevity experimenter and investor.

Founded Braintree, sold to PayPal for $800 million, and now runs Blueprint, a longevity experiment.

  • David Friedberg, Host · CEO, Ohalo

    Founded The Climate Corporation, sold to Monsanto for about $1.1B in 2013.

About this segment

Bryan Johnson describes feeling more playful and handling a conflict with his partner without escalating. It offers a concrete example of the changes he noticed after the experience.

From “Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World... Here's What It Was Like”, Mar 26, 2026. Watch the full episode

“like no need to escalate or to defend or to like it was just easy”
Bryan Johnsonat 12:17 · All-In12:17

Takeaways

  1. He says a disagreement with his partner felt easier to resolve.
  2. He noticed more humor and quickness in everyday conversation.
  3. He describes feeling renewed and more childlike afterward.

In this episode

Full episode
  1. 2:025-MeO-DMT felt like a complete release of the ego7:06
  2. 15:58Psychedelic risks depend partly on dose and setting7:35
  3. 26:17Cellular switches may control gene rejuvenation dosing7:10

  4. 10:34Johnson describes a calmer response to conflict after 5-MeO-DMT2:28

  5. 23:31Johnson links his openness to a rigid religious childhood2:48Up next
  6. 35:05Psychedelics may help preserve a youthful outlook2:20

Transcript

Transcribed by machine (Whisper) from the episode’s audio, so a word may be off here and there.

  1. 10:40

    i woke up uh catching myself laughing in a dream i have not laughed in a dream i don't even know when i've ever laughed in a dream but that is i after i woke up i was like that's really weird like i don't remember laughing i looked it up like that is a characteristic of a child right and so you are restored to this childlike state and i mean the past couple days uh i have felt childlike you know yesterday morning i felt that you know that emergent excitement the bubbling of like today's so exciting i'm going to do new things i'm going to have new experiences um that you're just excited about all things i haven't felt that i don't even know when you know for so many years so like it really was um profound on every layer and i see and i'm stumbling too because i don't even know how to talk about it yet during the day you're hanging out you're walking around

  2. 11:30

    is your brain having the same normal chatter that it did before or do you think that there's a persistent change in that default mode network yeah definitely a change like with i was with my partner kate yesterday and we um i did something that made her upset and so like in that situation you know like when when couples are in that moment you have like this negotiation how do i sort this and it all just became so clear to me Like when children have a fight, you have it out and then it's just like done and you move on.

  3. 12:05

    But then adults take that and they like package it up and like they wanna weaponize it and be like, I got something on you and I'm like, move it. I'm gonna move the chess pieces and like try to leverage this and- Or they stored up like a snake in one of those things that pops out all the snakes later. You know, it's like package it all up. Exactly. And so like we had this and I just felt absolutely like no need to escalate or to defend or to like it was just easy and um it was a breakthrough in our relationship where i was able to communicate with her in a way and so it's like laughing in my sleep it's how i deal with my partner when i walk around i just feel so much i uh i feel so much more funny you know like my ability to make quips that are just immediate uh you know like so yeah I just feel renewed as a person in a way that I just really didn't imagine have you tried