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All-In · 2 min · Mar 26, 2026

Psychedelics may help preserve a youthful outlook

Bryan Johnson distinguishes physical rejuvenation from a possible renewal of outlook, saying psychedelics may sustain a youthful, can-do disposition. He describes his own experience as decades of psychological rejuvenation.

Bryan Johnson is a longevity experimenter and investor.

Founded Braintree, sold to PayPal for $800 million, and now runs Blueprint, a longevity experiment.

David Friedberg, Host · CEO, Ohalo
Founded The Climate Corporation, sold to Monsanto for about $1.1B in 2013.

About this segment

Bryan Johnson distinguishes physical rejuvenation from a possible renewal of outlook, saying psychedelics may sustain a youthful, can-do disposition. He describes his own experience as decades of psychological rejuvenation.

From “Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World... Here's What It Was Like”, Mar 26, 2026. Watch the full episode

“Psilocybin and 5-MeO won't be meaningful for basic functions of the body, but maybe it's the outperformer in youthfulness of your disposition towards reality.”

Bryan Johnsonat 35:53 · All-In35:53

Takeaways

He says psychedelics may affect outlook in ways body therapies do not.
He connects them with a renewed sense that anything is possible.
He says the experience felt like decades of psychological rejuvenation.

In this episode

2:025-MeO-DMT felt like a complete release of the ego7:06
15:58Psychedelic risks depend partly on dose and setting7:35
26:17Cellular switches may control gene rejuvenation dosing7:10
10:34Johnson describes a calmer response to conflict after 5-MeO-DMT2:28
23:31Johnson links his openness to a rigid religious childhood2:48
35:05Psychedelics may help preserve a youthful outlook2:20

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Transcript

Transcribed by machine (Whisper) from the episode’s audio, so a word may be off here and there.

35:11
that seem to be biologically proven and have these profound effects why continue to tinker with psychedelics? Like, are they as profound? Are they a compliment? Or like, how do you think about fitting all of this portfolio of things that you're looking at together? Yeah. I mean, I guess the question is, I forget on the FOXO3 study, I don't know if they saw brain rejuvenation. Didn't see that. I did not see that. And I don't, I don't remember. I mean, it is a very complicated organ. Yeah, exactly. And it's insane. It's very hard to reach. You know, you can grow muscle tissue back and you can grow skin tissue back. And it's kind of like, okay, I grew a little x like if you grow the the neurons back maybe in the wrong way or like we don't know yeah because it's never been done before yeah so understanding the consequence of neuro regeneration
35:55
is like so I wonder like if the role in that play like you know maybe Psilocybin and 5-MeO won't be meaningful for basic functions of the body, but maybe it's the outperformer in youthfulness of your disposition towards reality. like one thing i'm apprehensive about is i'm 48 and so as you start climbing to your 50s 60s you do really narrow like your ambition goes from i can do anything to start you know narrowing down further and further and i worry about using losing a youthful disposition of a can-do attitude of anything is possible totally and maybe that's the role of psychedelics is you just get a wash of like the snap back of like i can and i can bounce yeah that definitely been the case for me so i think they do probably play a really important role of like they're probably a set of things that for certain people that will um basically like i mean i felt like it was like
37:00
30 40 years of psychological rejuvenation like you know it's like to transform me back to a childlike state yeah that is insane i don't get that from the sauna yeah or from eating well or Like I'm still, so it's just unique. Yeah. Amazing. Well, listen, I'm going to go drink alcohol